Checked 2026-11-10. Independent clinical review has not been completed. WADAFUK is independent of WADA and does not provide medical advice or an individual anti-doping determination.
Prohibited at all times
2026: prohibited at all times (S0). [1]
2026 List, S0, printed page 4 · 2026 rules apply from 1 January 2026. Any 2027 material below concerns future rules from 1 January 2027; it is not current clearance.
Identity and proposed mechanism
S-107 is an experimental Rycal compound studied for stabilizing the RyR1 calcium-release channel complex in skeletal muscle. In the cited experiments it helped preserve calstabin1 association with RyR1 and limit abnormal calcium leakage. [2]
What the original study did
Bellinger and colleagues combined human exercise-biopsy observations with experiments in mice. The S-107 intervention was in mice: treadmill and isolated-muscle measurements supported a protective effect against exercise-related fatigue in that model. The human cyclists were not treated with S-107, so their biopsy findings are not a human drug trial. [2]
- Animal endurance and laboratory muscle-force findings do not establish an effective or safe human performance treatment.
Limits and exposure context
The paper disclosed company shareholding, advisory or consulting interests. It does not supply clinical safety, long-term outcomes or a validated consumer-product exposure route. A marketed S-107 label cannot be verified from these experiments. [2]
What remains uncertain
- Ageing and later mechanistic papers in the original draft could not be reliably reopened and are not used for additional claims.
- No human efficacy or safety conclusion is supported by the checked primary study.
Check the sources.
These are concise editorial paraphrases of selected sources, not a systematic review or a reproduction of source tables. Access depth is shown for each reference; an abstract-only check cannot resolve details found only in a full paper.
- WADA 2026 Prohibited List ↗Accessed 2026-11-10 · official_full_text_relevant_sections
Effective date; S0 printed page 4; S2 printed pages 7–8
- Bellinger et al. 2008: RyR1 remodelling and exercise-induced muscle fatigue ↗Accessed 2026-11-10 · full_text_relevant_sections
PNAS 105:2198–2202; human biopsy and mouse intervention methods/results; conflict disclosure
Check the current official WADA List and the relevant anti-doping authority for your sport, product, route and circumstances. Do not stop or change necessary treatment based on this page. Ask a qualified clinician about health decisions. Missing evidence does not establish safety.