Checked 2026-11-10. Independent clinical review has not been completed. WADAFUK is independent of WADA and does not provide medical advice or an individual anti-doping determination.
Prohibited at all times
2026 S4.3: prohibited at all times. Non-Specified. [1]
S4.3 · 2026 rules apply from 1 January 2026. Any 2027 material below concerns future rules from 1 January 2027; it is not current clearance.
Clinical research
ACE-031 is an activin-receptor-IIB/Fc fusion protein designed to bind myostatin and related ligands. A randomized placebo-controlled study in ambulatory boys with Duchenne muscular dystrophy was stopped after nosebleed and telangiectasia concerns. Functional and body-composition trends were not proof of efficacy. [2]
- Primary-study abstract accessed through the authors’ institution; the full clinical paper was not appraised.
Product identity and exposure
A 2025 analytical study tested 14 products sold as ACE-031. Twelve contained an activin-receptor-IIB-reactive protein, but further testing identified full-length receptor rather than the intended ACE-031 fusion protein. A product name therefore did not reliably identify its contents. [3]
- Selected black-market products, not a representative survey of all products or current stock. No human safety experiment was performed.
Check the sources.
These are concise editorial paraphrases of selected sources, not a systematic review or a reproduction of source tables. Access depth is shown for each reference; an abstract-only check cannot resolve details found only in a full paper.
- WADA 2026 Prohibited List ↗Accessed 2026-11-10 · Relevant official full-text sections opened
Printed pp. 3, 9–12: introduction, S3, S4 and S5 as applicable
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial ↗Accessed 2026-11-10 · Primary-study abstract on author institution record
Primary-study abstract
- Gel Electrophoretic Detection of Black Market ACE-031 ↗Accessed 2026-11-10 · Relevant document text opened
Relevant cited sections
Check the current official WADA List and the relevant anti-doping authority for your sport, product, route and circumstances. Do not stop or change necessary treatment based on this page. Ask a qualified clinician about health decisions. Missing evidence does not establish safety.