INDEPENDENT ANTI-DOPING REFERENCE2026 · CHECKED 08 NOV 2027 PUBLISHED ↗
WADAFUK!?
Source-checked educational research

4-Androstene-3,6,17-trione.

S4
Source-checked educational research

Checked 2026-11-10. Independent clinical review has not been completed. WADAFUK is independent of WADA and does not provide medical advice or an individual anti-doping determination.

REGULATORY SUMMARY2026 LIST

Prohibited at all times

2026 S4.1: prohibited at all times. Specified. [1]

S4.1 · 2026 rules apply from 1 January 2026. Any 2027 material below concerns future rules from 1 January 2027; it is not current clearance.

EVIDENCE / 01

Human research

A small study assigned 16 resistance-trained men to two 6-OXO supplement groups for eight weeks. Hormone measures changed from baseline, but body composition did not. The design compared two active-dose groups, without a placebo group; unchanged measured laboratory safety markers do not establish long-term safety. [2]

Limits of this evidence
  • Small, short study in eugonadal men; neither a clinical approval nor evidence of athletic benefit.
EVIDENCE / 02

Historical safety and exposure report

Health Canada issued a warning after a person taking both 6-OXO and 1-AD developed seizures and cerebral blood clots. This documents a serious reported event involving combined use and historical supplement marketing; it does not isolate causation to 6-OXO. [3]

Limits of this evidence
  • Archived warning; not a current product inventory or a quantified risk estimate.
TRACEABILITY

Check the sources.

These are concise editorial paraphrases of selected sources, not a systematic review or a reproduction of source tables. Access depth is shown for each reference; an abstract-only check cannot resolve details found only in a full paper.

  1. WADA 2026 Prohibited List ↗Accessed 2026-11-10 · Relevant official full-text sections opened

    Printed pp. 3, 9–12: introduction, S3, S4 and S5 as applicable

  2. Rohle et al 2007 6-OXO trial ↗Accessed 2026-11-10 · Relevant document text opened

    Relevant cited sections

  3. Health Canada 6-OXO/1-AD warning, 2008 ↗Accessed 2026-11-10 · Relevant document text opened

    Relevant cited sections

Before acting on this information

Check the current official WADA List and the relevant anti-doping authority for your sport, product, route and circumstances. Do not stop or change necessary treatment based on this page. Ask a qualified clinician about health decisions. Missing evidence does not establish safety.

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